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 Consistently Appraise individuals by using a history of seizure Diseases for worsened seizure Manage in the course of DEMEROL Tablets and Oral Option therapy. Utilization of DEMEROL Tablets and Oral Alternative for an extended timeframe might enhance the threat of toxicity (e.g., seizures) with the accumulation in the meperidine metabolite, no
The concomitant utilization of DEMEROL Tablets or Oral Alternative and CYP3A4 or CYP2B6 inducers can decrease the plasma focus of meperidine [see Medical Pharmacology (12.3)], causing lessened efficacy or onset of a withdrawal syndrome in clients that have developed Bodily dependence to meperidine [see Warnings and Safety measures (five.In the